OLIVER EICKELBERG, MD
MD, University of Luebeck, Germany, and University of Basel, Switzerland
Tissue injury and repair
Our scientific focus is basic, translational, and clinical research deciphering the mechanisms of tissue fibrosis, particularly in progressive forms of interstitial lung disease (ILD) including idiopathic pulmonary fibrosis (IPF), rheumatoid arthritis-associated ILD (RA-ILD), and chronic rejection after lung transplantation. My research has mechanistically interrogated profibrotic signaling pathways (TGF-beta, Wnt) that control the dynamics of extracellular matrix (ECM) composition and resident cell-ECM interaction during tissue injury, repair, and fibrosis. I have significant expertise in deciphering resident lung cell function (fibroblasts, epithelial cell types, and plasma cells) in homeostasis and disease. Recently, we have characterized the entire transcriptome and proteome during lung injury, repair, fibrosis, and regeneration, in animal models as well as human disease, using high-content genomic and proteomic approaches. We aim to mechanistically interrogated mechanisms that contribute to tissue fibrosis, particularly during chronic rejection after lung transplantation. Our lab has developed several improvements to animal models of orthotopic lung transplantation and graft preservation. I am dedicated to effective mentoring, training, and promotion in an inclusive and open-minded scientific environment to foster career development of my trainees and mentees.