Focus Areas

Emerging roles of T cells in Transplantation

Although T cells are the primary drivers of transplant rejection and GVHD, recent discoveries have uncovered novel T cell subsets and cytokines that orchestrate the immune response and contribute to either tissue injury or repair.  Research at the STI addresses many of these emerging roles of T cells using cutting-edge cellular, molecular, and computational techniques.

Heth Turnquist
Heth Turnquist
Oliver Eickelberg
Oliver Eickelberg
Fadi Lakkis
Hossam Abdelsamed
Diana Metes
John McDyer
John McDyer
Mark Snyder
Mark Snyder
Diana Metes
Geoffrey Camirand
Mohammed Ezzelarab
Warren Shlomchik
Faruk Sacirbegovic
Khodor Abou-Daya
Heth Turnquist
Heth Turnquist
Heth Turnquist
Heth Turnquist
Fadi Lakkis
Oliver Eickelberg
Oliver Eickelberg

Emerging roles of B cells in Transplantation

It is now recognized that B cells are not only precursors of Ab-producing cells but also have antigen-presenting, regulatory, and effector functions.  Our research efforts aim at understanding how these functions contribute to rejection and influence clinical allograft outcomes.

Geetha Chalasani
David Rothstein
David Rothstein
Diana Metes
Qing Ding
David Rothstein
David Rothstein
Qing Ding
Aravind Cherukuri
Aravind Cherukuri
Adriana Zeevi
Adriana Zeevi
Diana Metes

Innate Alloimmune Responses

The innate immune system plays an important role in initiating adaptive alloimmunity.  Researchers at the STI have discovered that innate immune cells respond to non-self determinants on the graft tissue and generate innate memory cells, in addition to causing the inflammation that enhances immunity.  We now aim to further understand the molecular mechanisms of these pathways and how they can be exploited to improve tissue typing or to prevent rejection.

Fadi Lakkis
Martin Oberbarnscheidt
Khodor Abou-Daya
Angus Thomson
Angus Thomson
Mohammed Ezzelarab
Heth Turnquist
Heth Turnquist
Heth Turnquist
Heth Turnquist
Adrian Morelli
Matthew Nicotra
Heth Turnquist
Heth Turnquist
Martin Oberbarnscheidt
Camila Macedo
Samer Tohme
Samer Tohme

Improving Clinical Outcomes

Despite remarkable progress in short-term allograft survival, improvement in long-term allograft survival has been incremental and remains suboptimal.  STI clinicians and researchers are advancing novel predictive biomarkers, diagnostics, therapies, and organ preservation strategies that bring us closer to the goal of “one transplant for life” without increasing the burden of immunosuppression.

Cell Therapy

Heth Turnquist
Heth Turnquist
Oliver Eickelberg
Oliver Eickelberg

Biomarkers/Novel Diagnostics

David Rothstein
David Rothstein
Aravind Cherukuri
Aravind Cherukuri
Rakesh Sindhi
Rakesh Sindhi

Organ Preservation

Christopher Hughes
Christopher Hughes

Transplant Pathology

Parmjeet Randhawa
Parmjeet Randhawa
Anthony Jake Demetris
Anthony Jake Demetris
Michael Nalesnik
Michael Nalesnik
Michelle Wood-Trageser
Michelle Wood-Trageser

Tissue Typing

Adriana Zeevi
Adriana Zeevi
Qingyong Xu
Qingyong Xu

Immunosuppression

Raman Venkataramanan
Raman Venkataramanan

Epidemiological Studies/Outcomes Research

Sundaram Hariharan
Puneet Sood
Rajil Mehta
Aravind Cherukuri
Aravind Cherukuri

Tolerance

Angus Thomson
Angus Thomson

Pediatric Liver Transplantation

George Mazariegos
Rakesh Sindhi
Rakesh Sindhi
Ira Fox
Ira Fox

Lung Transplantation

John McDyer
John McDyer
Mark Snyder
Mark Snyder
Oliver Eickelberg
Oliver Eickelberg
Xingan Wang
Xingan Wang

Liver Cancer / Hepatobiliary Surgery

David Geller
David Geller
Samer Tohme
Samer Tohme
Qiang Du
Qiang Du

Tissue Regeneration and Cell Transplantation

Ira Fox
Ira Fox
Alex Soto-Gutierrez
Alex Soto-Gutierrez