| University of Pittsburgh |  |
UPMC | |
Health Sciences @ Pitt | |
STI Clinical Website | |
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| Faculty | |
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Fadi G. Lakkis
, M.D.
Scientific Director, Thomas E. Starzl Transplantation Institute Frank and Athena Sarris Chair in Transplantation Biology Professor of Surgery and Immunology Biomedical Science Tower, W1542 200 Lothrop Street Pittsburgh, PA 15261 Phone: (412) 383-5774 Email: lakkisf@upmc.edu Faculty Research Interests Personal Web Page |
| Academic Affiliations | |
| Surgery, Immunology | |
| Education | |
| 1985-1986 Research Fellow, Internal Medicine BIDMC Harvard Medical School Boston, MA 1986-1989 Intern & Resident, Internal Medicine Wayne State University School of Medicine Detroit, MI 1989-1992 Research & Clinical Fellow, Nephrology BIDMC Harvard Medical School Boston, MA |
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| Areas of Research Interest | |
| Basic Research, Translational Research, Tolerance Induction, Immunologic Monitoring, Innate Immunity, Lymphoid Neogenesis, Imunological Ignorance, Memory T Cells |
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| Research Interests | |
| My research interests are focused on three fundamental areas in transplantation immunobiology: 1. Allorecognition in the innate immune system. Both invertebrate and vertebrate (mouse) models of transplantation are employed to investigate the earliest innate signals that trigger rejection. 2. Role of lymphoid tissues in the initiation and propagation of the alloimmune response. We are currently studying whether ectopic lymphoid tissues that develop within the graft are involved in either acute or chronic rejection. 3. The biology of memory T cells in organ transplantation. We are currently investigating how memory T cells migrate to a transplanted organ and what is required for their activation and maintenance. |
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| Publications | |
| 1. Powell AE, Nicotra ML, Moreno MA, Lakkis FG, Dellaporta SL, Buss LW. Differential effect of allorecognition loci on phenoytpe of Hydractinia symbiolongicarpus (Cnidaria:Hydrozoa). Genetics 2007; 177(4):2101-2107. 2. Obhrai JS, Oberbarnscheidt M, Zhang N, Mueller DL, Shlomchik WD, Lakkis FG, Shlomchik MJ, Kaplan DH. Langerhans cells are not required for efficient skin graft rejection. Journal of Investigative Dermatology 2008; 28:1950–1955. 3. Zecher D, Lakkis FG. Ignorance is bliss [editorial]. Blood 2008; 111:4426-4427. 4. Poudyal M, Rosa S, Powell AE, Moreno M, Dellaporta SL, Buss LW, Lakkis FG. Embryonic chimerism does not induce tolerance in an invertebrate model organism. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4559-64. 5. Nasr IW, Reel M, Oberbarnscheidt MH, Mounzer RH, Baddoura FK, Ruddle NH, Lakkis FG. Tertiary lymphoid tissues generate effector and memory T cells that lead to allograft rejection. Am J Transplant. 2007 May;7(5):1071-9. 6. Obhrai JS, Oberbarnscheidt MH, Hand TW, Diggs L, Chalasani G, Lakkis FG. Effector T cell differentiation and memory T cell maintenance outside secondary lymphoid organs. J Immunol. 2006 Apr 1;176(7):4051-8. |
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| Honors/Awards | |
| 1985 Alpha-Omega-Alpha Honor Medical Society 1990 The National Kidney Foundation and The American Society of Nephrology prize for excellence in research 1996 Young Investigator Award of the Transplantation Society 1999 The Wyeth-Ayerst Young Investigator Award of the American Society of Transplantation 2002 Elected member, American Society of Clinical Investigation 2002 Young Investigator Award of the American Society of Nephrology 2001 – 2004 Board Member, American Society of Transplantation |
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| Memberships | |
| American Society of Transplantation American Society of Nephrology International Society of Nephrology American Association of Immunologists American Society of Clinical Investigation |
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| Long-Term Laboratory Personnel | |
| Geoffrey Camirand, Ph.D. Post-Doctoral Fellow Qi Li Research Instructor Isam Nasr Surgery Resident/Research Fellow Martin Oberbarnscheidt Research Fellow Dawn Reichenbach Graduate Student (Immunology) Sabrina Rosa Research Assistant, Graduate Student – Free University of Brussels, Belgium Tiffany Simmons Research Assistant Christine Straznick Administrative Assistant Jeffrey Walch MD-PhD Student John Walters Research Assistant Amanda Williams Lab Manager Daniel Zecher Post-Doctoral Fellow |
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