| University of Pittsburgh |  |
UPMC | |
Health Sciences @ Pitt | |
STI Clinical Website | |
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| Faculty | |
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David K. C. Cooper
, M.D., Ph.D.
Professor of Surgery Biomedical Science Tower, W1543 200 Lothrop Street Pittsburgh, PA 15213 Phone: (412) 383-6961 Email: cooperdk@upmc.edu Fax: (412) 624-1172 Faculty Research Interests Personal Web Page |
| Academic Affiliations | |
| School of Medicine, Department of Surgery | |
| Education | |
| Completion of training in general and cardiovascular surgery in the United Kingdom Ph.D. in surgical research, University of London, United Kingdom |
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| Areas of Research Interest | |
| Tolerance Induction, Xenotransplantation, Islet Cell Transplantation | |
| Research Interests | |
| The research interests of my group are primarily in the field of xenotransplantation, both of whole organs and of pancreatic islets. We have access to α1,3–galactosyltransferase gene-knockout pigs and other genetically- modified pigs from our collaborators at Revivicor, Inc., and we are currently testing these in several pig-to-nonhuman primate models. We also have an interest in islet allotransplantation as a treatment for diabetes. | |
| Publications | |
| 1. Rood, P.P.M., Bottino, R., Balamurugan, A.N., Smetanka, C., Ayares, D., Groth, C-G., Murase, N., Cooper, D.K.C., Trucco, M. Reduction of early graft loss after intraportal porcine islet transplantation in monkeys. Transplantation 2007;83:202-210. 2. Tai, H-C., Ezzelarab, M., Hara, H., Ayares, D., Cooper, D.K.C. Progress in xenotransplantation following the introduction of gene-knockout technology. Transplant Int 2007;20:107-117. 3. Zhu, X., Dor, F.J.M.F., Cooper, D.K.C. Pig-to-nonhuman primate heart transplantation: immunologic progress over 20 years. J Heart Lung Transplant 2007;26:210-218. 4. Rood, P.P.M., Tai, H-C., Hara, H., Long, C., Ezzelarab, M., Lin, Y.J., van der Windt, D., Busch, J, Ayares, D., Ijzermans J.N.M., Wolf, R.F., Manji, R., Bailey, L., Cooper, D.K.C. Late onset of development of natural anti-nonGal antibodies in infant humans and baboons: implications for xenotransplantation in infants. Transplant Int 2007;20:1050-1058. 5. Cooper, D.K.C., Dorling, A., Pierson, R.N. III, Rees, M., Seebach, J., Yazer, M., Ohdan, H. Awwad, M., Ayares, D. α1,3-galactosyltransferase gene-knockout pigs for xenotransplantation: where do we go from here? Transplantation 2007;84:1-7. 6. Casu, A., Bottino, R., Balamurugan, A.N., Hara, H., van der Windt, D., Campanile, N., Smetanka, C., Cooper, D.K.C., Trucco, M. Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice. Diabetologia 2008;51: 120-129. 7. Ezzelarab, M., Welchons, D., Torres, C., Hara, H., Long, C., Yeh, P., Ayares, D., Cooper, D.K.C. Atorvastatin downregulates the primate cellular response to porcine aortic endothelial cells in vitro. Transplantation. 2008;86:733-737. 8. Hara, H., Long, C., Lin, Y.J., Tai, H-C., Ezzelarab, M., Ayares, D., Cooper, D.K.C. In vitro investigation of pig cells for resistance to human antibody-mediated rejection. Transplant Int. 2008;21:1163-1174. 9. Lin, C.C., Chen, D., McVey, J.H., Cooper, D.K.C., Dorling, A. Expression of tissue factor and initiation of clotting by human platelets and monocytes after incubation with porcine endothelial cells. Transplantation. 2008;86:702-709. 10. Cooper, D.K.C. Frankenswine, or bringing home the bacon: how close are we to clinical trials in xenotransplantation? (Invited paper) Organogenesis 2008;4:1-10. 11. Hara, H., Gridelli, B., Lin, Y.J., Marcos, A., Cooper, D.K.C. Liver xenografts for the treatment of acute liver failure – clinical and experimental experience and remaining immunologic barriers. Liver Transplantation. 2008;14:425-434. 12. van der Windt, D.J., Echeverri, G., Cooper, D.K.C. The choice of anatomical site for islet transplantation. Cell Transplantation. 2998;17:1005-1014. 13. Lin, C.C., Cooper, D.K.C., Dorling, A. Coagulation dysregulation as a barrier to xenotransplantation in the primate. Transpl Immunol. 2009; In press. |
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| Memberships | |
| Fellow, Royal College of Surgeons of England Fellow, American College of Surgeons Member, Transplantation Society Member, American Society of Transplant Surgeons Founding Member, International Xenotransplantation Association Member, American Society of Transplantation |
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| Long-Term Laboratory Personnel | |
| Hidetaka Hara, M.D., Ph.D. Instructor Mohamed Ezzelarab, M.D. Instructor Gabriel Echeverri, M.D. Postdoctoral Associate Burcin Ekser, M.D. Postdoctoral Associate Eefje Dons, M.D. Postdoctoral Associate Cassandra Long Research Technician |
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